We run an ESPN game, with a QB, 2 RB 2WR, an extra spot for a WR or a RB, a K, a D/ST, a TE, and an offensive player (can be QB, WR, RB, or TE).
I had Brees, Jamal Charles, Larry Fitzgerald, Tony Gonzalez, on draft day, got lucky to pick up Vick after week 1, Peyton Hillis after week 1, and David Garrad (sp?). Because our league doesn't limit trades, I would swap out D's based on how they were playing or who they were playing (tho I have used the Patriots for the last 6 or so weeks). I used Adam Vianitari (sp again) for a kicker, but dropped him for Feely at one point. I picked up Fred Jackson about week 4, and Vincent Jackson when he became available-- I used TO a lot of the season, until he got hurt. Todays roster was a little messy, due to a few players being injured, but it looked like this:
QB- Brees
RB-Charles
RB-Ryan Matthews (Picked him up a few weeks ago)
WR/RB-Larry Fitzgerald (this guy struggled this year, but I stuck with him)
WR-Mario Manningham (I took a hit a few weeks cause he came up 0 more than once)
WR-Vincent Jackson
TE-Brandon Pettigrew (Yeah, bad week to bench Tony)
OP-Rex Grossman
D/ST-Patriots
K-Feely
We have a 7 player bench. I started out the season something like 2-6, having a horrible time with the players I drafted (lots of busts, like Cin's D). I made a good run towards the end, finished the reg season 8-7, but was #2 in my division (we have 8 teams, 4 to a division). Got lucky that when I went up against number one last week, he had a lot of injuries.