My university library has a quiet room, but I can't use it because it's a no-laptop zone. The regular library area is supposed to be quiet, but as it's a huge hall with plenty of people, it never really is. Especially when large groups of people walk in or out, apparently oblivious to the idea that you're supposed to shut up in a library. There are small designated rooms for group work and one large one where you can talk, though.
So the fact that people will walk in laughing, talking on their phone or whatever and react sulky when you tell then to shut up is one thing that bothers me. The other thing is that people won't close the toilet doors, although there is a bilingual inscription on the toilet doors telling them to. So when I happen to be at one of the shelves nearby, toilet flushing and nose-blowing are among the more pleasant sounds you would hear. It really pisses me off, because some of the shelves I frequently stand in front of to check for a reference is right next to such a door.
Anyway, whenever I work at a desk I have my earphones in and am blasting something in my earbuds.